Andrea Sottoriva [ Curriculum Vitae ]

PhD student at the University of Cambridge
Computational Biology Group
Cancer Research UK Cambridge Research Institute
Li Ka Shing Centre, Robinson Way
CB2 0RE, Cambridge (UK)

hifi_AT_metalabs_DOT_org
as949_AT_cam_DOT_ac_DOT_uk

Research overview:
My research focuses on developing mechanistic, multi-scale mathematical models of cancer formation and progression using an evolutionary approach. I then use the models I create and implement, together with high-throughput sequencing data from patients or mouse xenografts (e.g. methylation patterns) to infer about the biology of the systems I simulate. In this last step I make use of Bayesian inference techniques, such as Approximate Bayesian Computation, to explore the physical and biological properties of malignancies and to address open questions in cancer biology that are otherwise off-limits for wet labs. In particular, I develop both Hybrid Cellular Automata (HCA) and Cellular Potts Models (CPM) to:

* Model tumor growth and invasion
* Model clonal expansion and phenotypical heterogeneity in tumors
* Model cancer stem cells
* Infer colon crypts dynamics
* Simulate crypt budding and fission

www.compbio.group.cam.ac.uk/People/Andrea/
www.cambridgecancer.org.uk